搜索:  
(Macromolecules) Oligodeoxynucleosides with Olefin Bridges  
(Macromolecules) Oligodeoxynucleosides with Olefin Bridges
资料类型: PDF文件
关键词: DNA  
资料大小: 883k
所属学科: 高分子化学
88必发娱乐官网: 88必发娱乐官网网络
简介:
The synthesis and self-assembly studies of DNA/RNA-mimic artificial polymers have drawn extensive scientific attention, since synthetic chemists can manipulate the functions of these modified nucleic acid molecules by varying their macromolecular backbone and nucleoside unit structures. In this manuscript, we report two types of modified nucleic acids with olefin bridges prepared by acyclic diene metathesis polymerization (ADMET). The 3’-OH and 5’-OH groups of deoxythymidine and deoxyadenosine analogue monomers are functionalized with either two terminal allyl units or allyl and acryloyl units respectively. The consequent ADMET approaches provide either regio-uncontrolled oligodeoxynucleosides with poor E/Z selectivity or well-defined oligodeoxynucleosides built in a highly ordered head-to-tail addition manner. These two different macromolecular structures markedly influence the self-assembly morphologies of the corresponding oligodeoxynucleosides, which show spherical and filamentous helix nanostructures respectively.
上传人: yangh
上传时间: 2019-02-17 18:18:04
下载次数: 0
消耗积分: 0  
立即下载:
1人
1人
1人
友情提示:下载后对该资源进行评论,即可奖励2分。
报告错误:  1.下载无效  2. 资料明显无价值  3. 资料重复存在

相关评论 共有0人发表评论 更多评论
你还没有登录,无法发表评论,请首先 登录 注册
免责声明:本站部分资源由网友推荐,来自互联网,版权属于原版权人,如果不慎侵犯到您的权利,敬请告知,我们会在第一时间撤除。本站中各网友的评论只代表其个人观点,不代表本站同意其观点。